Vitiligo News

Conclusions: The findings of this systematic review and meta-analysis suggest that UV phototherapy is a safe treatment for vitiligo with no significant risk of skin cancer.

Background: Although ultraviolet (UV) phototherapy is an effective treatment for vitiligo, its effect on the risk of skin cancer remains controversial.

Aim: To investigate the association between UV phototherapy and skin cancer risk in patients with vitiligo.

Methods: A systematic review was performed for studies published before 5 May 2021 in the PubMed, Embase, Web of Science and Cochrane Library databases. The primary outcome was the association of UV phototherapy with the risk of skin cancer in patients with vitiligo. A meta-analysis with a random-effects model was conducted.

Results: Five retrospective cohort studies covering a total of 228 607 patients with vitiligo (110 038 who had been treated with UV phototherapy and 118 569 patients who had not) were included in the meta-analysis. The risk of nonmelanoma skin cancer [Mantel-Haenszel risk ratio (MHRR) = 0.95; 95% CI 0.44-2.05] and melanoma (MHRR = 1.11; 95% CI 0.33-3.82) did not significantly increase after phototherapy in patients with vitiligo. In the subgroup analysis, we also found no significant association between phototherapy with narrowband UVB phototherapy specifically and risk of skin cancer in patients with vitiligo. There was no significant difference in risk of skin cancer between patients from Europe and those from East Asia and the risk was not affected by the number of narrowband UVB phototherapy sessions.

https://pubmed.ncbi.nlm.nih.gov/34762747/

Impact of narrow-band ultraviolet B radiation therapy on the quality of life of patients with vitiligo

Conclusion: NB-UVB therapy is effective in alleviating psychological stress and improving the quality of life of patients with vitiligo.

Objectives: Patients with vitiligo experience emotional and psychological stress as they undergo long-term therapy. The debilitating psychosocial effects of this disease on patients' quality of life is well-documented. This study evaluates the effect of the introduction of narrow-band ultraviolet-B (NB-UVB) therapy on the quality of life of patients with vitiligo in Almadinah Almunawwarah, KSA.

Methods: Thirty-eight patients from the main dermatology center of Ohud Hospital, Almadinah Almunawwarah, were interviewed between June 2017 and March 2019 using the Dermatology Life Quality Index (DLQI) questionnaire. The interviews were conducted before and one year after the course of NB-UVB therapy, which was added as a new treatment modality to the basic therapeutic regimen of topical medications.

Results: The patients' response to vitiligo therapy was positive. The overall patient satisfaction score regarding the NB-UVB therapy was as high as 9.1 out of 10. The initial overall DLQI score (5.67 ± 0.90) markedly decreased after the NB-UVB therapy (3.08 ± 0.56), indicating a significant improvement. The patients' adherence to the follow-up visits also improved.

https://pubmed.ncbi.nlm.nih.gov/34899128/

Combination of carboxytherapy with NB-UVB leads to higher percentage of repigmentation and patients' satisfaction compared to monotherapy with NB-UVB.

Carboxytherapy has been used in the treatment of autoimmune skin diseases such as psoriasis and morphea. Carboxytherapy has antioxidant effects, and leads to better tissue oxygenation, and release of growth factors. In this article, we decided to evaluate efficacy of combined carboxytherapy and narrowband-ultraviolet B (NB-UVB) compared to NB-UVB alone in the treatment of vitiligo. This is a prospective, split-body double-blind comparative study performed in patients with generalized stable vitiligo in acral areas and extremities referred to dermatology clinic of Afzalipour hospital in Kerman University of Medical Sciences. NB-UVB was performed three times a week in non-consecutive days for 4 months. In each patient, one lesion was randomly treated with carboxytherapy (weekly sessions for total of 16 sessions). Efficacy of treatment was evaluated by percentage of repigmentation of the lesions. Chi-square test and analysis of variance test (ANOVA) were used to compare efficacy of treatment based on demographic features of the patients and clinical features of the lesions, respectively. Twenty-eight patients with mean age of 32.35 ± 7.37 years old completed the study. At the end of the treatment, 37% of the patients in combination therapy group demonstrated more than 75% improvement compared to 0% in the monotherapy group (p = 0.001). There was no significant difference between either demographic features of the patients (age, sex, and skin phototypes) or duration of disease with efficacy of the treatment in both groups. Combination of carboxytherapy with NB-UVB leads to higher percentage of repigmentation and patients' satisfaction compared to monotherapy with NB-UVB.

https://pubmed.ncbi.nlm.nih.gov/34820974/

Idiopathic non-inflammatory leukoderma in horses have differentnames for these circumstances, concerns Pinky or Fading syndrome. Die in the perception that you know the importance of vitiligo. Vitiligo also affects other others and some animals. The shape and size of the vitiligo can be spontaneous. Vitiligo can manage the snout, face and genital areas and any area of ​​the horse that is fine-haired. There is no 100% treatment. What you see is probably only cosmetic and not harmful to the horse. Some need vitamin or mineral deficiency to monitor vitiligo. Therefore, you have maintained your feeding routine and completed a supplement to manage any deficit. Vitiligo also gilds as hereditary and in some breed counts.

This great article includes all you need to know about Leucoderma and gives you key-points in how to manage your life with this skin condition.

Link to full article:

https://www.gponline.com/management-patients-vitiligo/dermatology/article/1373737

management-patients-vitiligo/leucoderma/dermatology

In the Journal of the American Academy of Dermatology a link has been fount by various studies that multiple new disease associations with vitiligo, including multiple sclerosis, idiopathic thrombocytopenic purpura (ITP), and lymphoma. Study results also affirmed known associations between vitiligo and certain autoimmune diseases, including hypothyroidism and rheumatoid arthritis.

Investigators conducted a retrospective cohort study of patients with vitiligo who presented to NYU Langone Medical Center for medical care. All available records from 2005 to 2015 were reviewed. Demographic and clinical data were extracted, including vitiligo type and body surface area of involvement. Medical history, including the presence of comorbid conditions, was assessed. Univariate analyses were performed to compare the prevalence rates of each comorbidity in the patient cohort.

The study cohort comprised 1487 patients with vitiligo, among whom 55.1% were women and 46.7% were white. The most common comorbidities were hypothyroidism and rheumatoid arthritis, which were present in 7.6% and 1.6% of the cohort, respectively. Compared with the general population, the vitiligo cohort had a 1.65-fold higher prevalence of hypothyroidism (P <.0001) and a 2.14-fold higher prevalence of rheumatoid arthritis (P =.001).

Patients also had a significantly higher prevalence of multiple sclerosis (4.48-fold increase; P <.0001), ITP (70-fold increase; P <.0001), seronegative arthritis (3.68-fold increase; P <.0001), pernicious anemia (2.73-fold increase; P =.012), myasthenia gravis (13.33-fold increase; P <.0001),

Could there be a link to Vitiligo as today, early greying of hair is a common problem. Although this hair varies from person to person and grey hair can be more unruly than other strands. This condition is pretty much inevitable with age. It is a reminder that you are growing older. However, some people start to go grey at an very early age. and here we ask what is the reason behind premature greying of hair.

Genetic: Early greying can be due to your genes. If your mother or father became grey early, you may too.

Insufficient melanin production: Hair gets its colour from a pigment called melanin. It is produced by melanocyte cells in the hair follicles. Melanocytes endure cumulative damage over the years which eventually leaves them unable to produce melanin. Thus in the absence of melanin, the new hair that grows in has no pigment and it appears grey, white or silver.

The largest ever trial testing UVB treatment for Vitiligo has been completed by the NHS in Nottingham. You can read more details of this successful trial here:

https://www.nottingham.ac.uk/research/groups/cebd/projects/2vitiligo/vitiligo-maintrial.aspx

This is the real story of a 33 year old woman published in the Daily Mail

According to a recent case-control study published in the Journal of Cosmetic Dermatology, narrow-band ultraviolet B (NB-UVB) therapy increases serum 25-hydroxyvitamin D and decreases symptoms in patients with vitiligo.

We found this article and want to publish it here in full:

Vitamin D improves vitiligo